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Subject-specific estimation of central aortic blood pressure using an individualized transfer function: a preliminary
Jin-Oh Hahn1, Andrew T Reisner, Farouc A Jaffer
1Department of Mechanical Engineering, University of Alberta, Edmonton, AB T6G2G8 Canada. jinoh.hahn@alum.mit.edu
Summary
This study introduces an individualized transfer function (ITF) to estimate central aortic blood pressure from peripheral measurements. The ITF significantly improves accuracy, especially in non-standard physiological conditions.
Area of Science:
- Biomedical Engineering
- Cardiovascular Physiology
- Medical Signal Processing
Background:
- Accurate estimation of central aortic blood pressure (CABP) is crucial for cardiovascular assessment.
- Existing methods for CABP estimation often lack accuracy, particularly in non-ideal physiological states.
- Peripheral blood pressure (PBP) is easily measured but requires accurate conversion to reflect CABP.
Purpose of the Study:
- To develop and validate a novel physics-based approach for estimating CABP waveform from PBP waveform.
- To introduce a subject- and state-specific individualized transfer function (ITF) for improved CABP estimation.
- To demonstrate the experimental proof-of-principle of the ITF in an in vivo setting.
Main Methods:
- Development of a physics-based model to derive an individualized transfer function (ITF).
- Experimental validation of the ITF using an in vivo protocol in swine subjects.
- Comparison of ITF-based CABP estimation against a non-individualized transfer function across diverse physiological conditions.
Main Results:
- The ITF demonstrated superior accuracy in estimating CABP waveforms compared to non-individualized methods.
- Significant reductions were observed in root-mean-squared error (30%) and systolic/pulse pressure errors (>50%) (p < 10^-4).
- The ITF led to a statistically significant reduction in estimation errors exceeding 3 mmHg (p < 10^-4).
Conclusions:
- The individualized transfer function (ITF) offers a promising alternative for estimating central aortic blood pressure.
- The ITF shows particular utility in physiological conditions that deviate from normative values.
- This approach may enhance the clinical assessment of cardiovascular health by improving CABP waveform estimation.
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