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Quantifying the Antifungal Activity of Peptides Against Candida albicans
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A novel lanosterol isomer produced in response to azole antifungals
1Institute of Dermatology, UMDS, St Thomas' Hospital, London, England.
Journal of Steroid Biochemistry
|August 14, 1990
Abstract:
Gas chromatography-mass spectrometry has revealed the existence of a novel lanosterol-like sterol which is produced by fungi in response to treatment with azole drugs. The significance of this finding may be related to the changes in fungal sterol synthesis as a consequence to prolonged exposure to azoles and consequent development of resistance to these agents.
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