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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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Fluoroquinolone resistance in Staphylococcus intermedius.

D H Lloyd1, A I Lamport1, W C Noble2

  • 1Department of Small Animal Medicine and Surgery, Royal Veterinary College, London.

Veterinary Dermatology
|October 14, 2021
PubMed
Summary
This summary is machine-generated.

Four dog Staphylococcus intermedius isolates showed enrofloxacin resistance. Two also resisted marbofloxacin and ciprofloxacin, though the quinolone resistance mechanism in S. intermedius remains unconfirmed.

Keywords:
Staphylococcus intermediusdogsenrofloxacin resistancefluoroquinolonesgyrA

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Area of Science:

  • Veterinary Microbiology
  • Antimicrobial Resistance
  • Canine Bacterial Infections

Background:

  • Staphylococcus intermedius is a common canine pathogen.
  • Quinolone antibiotics like enrofloxacin are used in veterinary medicine.
  • Antimicrobial resistance in bacteria poses a significant One Health challenge.

Purpose of the Study:

  • To investigate the prevalence of enrofloxacin resistance in canine Staphylococcus intermedius isolates.
  • To determine the cross-resistance patterns to other fluoroquinolones.
  • To explore the potential molecular mechanisms of quinolone resistance in this species.

Main Methods:

  • Bacterial isolation and identification from canine samples.
  • Antimicrobial susceptibility testing using standard methods.
  • Phenotypic characterization of resistance patterns.

Main Results:

  • Four out of 429 canine isolates of Staphylococcus intermedius exhibited resistance to enrofloxacin.
  • Two of these resistant isolates also showed resistance to marbofloxacin and ciprofloxacin.
  • The specific molecular mechanism for quinolone resistance could not be confirmed in these isolates.

Conclusions:

  • Enrofloxacin resistance is present in canine Staphylococcus intermedius.
  • Co-resistance to other clinically relevant fluoroquinolones is a concern.
  • Further research is needed to elucidate the genetic basis of quinolone resistance in Staphylococcus intermedius.