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Related Experiment Video

Updated: May 26, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Primary malignant rhabdoid melanoma.

Bo Young Chung¹, In Su Ahn, Soo Ick Cho

¹Department of Dermatology, College of Medicine, Hallym University, Seoul, Korea.

Annals of Dermatology

|December 8, 2011

Summary

This study details a rare primary malignant melanoma exhibiting rhabdoid features. The tumor, composed entirely of rhabdoid cells, was successfully excised with no signs of recurrence.

Keywords:

Malignant melanoma Rhabdoid

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Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

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Published on: September 13, 2019

Area of Science:

Oncology
Dermatopathology

Background:

Malignant melanoma is a significant skin cancer.
Rhabdoid features are an uncommon presentation in malignant melanoma.

Observation:

A 54-year-old male presented with a primary malignant melanoma on his right forearm.
Histopathology revealed a tumor composed exclusively of neoplastic cells with rhabdoid morphology, characterized by eccentric nuclei and hyaline cytoplasmic inclusions.

Findings:

Immunohistochemical analysis showed tumor cell reactivity for HMB-45, S100, Fontana-Masson silver, and vimentin.
The tumor cells were negative for smooth muscle actin, CD68, CD34, CD99, synaptophysin, desmin, and PAS, aiding in differential diagnosis.

Implications:

This case highlights the importance of recognizing primary rhabdoid malignant melanoma.
Accurate diagnosis is crucial for differentiating from other neoplasms like malignant peripheral nerve sheath tumor or rhabdomyosarcoma.
Successful surgical management with wide excision and skin grafting offers a positive prognosis.