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Gender and cervical artery dissection.

A J Metso1, T M Metso, S Debette

  • 1Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland. antti.metso@helsinki.fi

European Journal of Neurology
|December 14, 2011
PubMed
Summary
This summary is machine-generated.

Cervical artery dissection (CeAD) is more frequent in men, who are also older at dissection. Gender differences in risk factors may contribute, but these factors are not specific to CeAD.

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Area of Science:

  • Neurology
  • Vascular Medicine
  • Epidemiology

Background:

  • Cervical artery dissection (CeAD) is a significant cause of stroke, particularly in younger adults.
  • Established gender differences in CeAD incidence and age at presentation exist.
  • Understanding these gender disparities is crucial for effective prevention and treatment strategies.

Purpose of the Study:

  • To comprehensively analyze and confirm previously observed gender differences in cervical artery dissection (CeAD).
  • To investigate potential gender-specific risk factors contributing to CeAD.
  • To compare gender-related findings in CeAD patients with those experiencing non-CeAD ischemic stroke.

Main Methods:

  • A large case-control study utilizing the CADISP (Cervical Artery Dissection and Ischemic Stroke Patients) cohort.
  • Inclusion of 983 consecutive CeAD patients and 658 control patients with non-CeAD ischemic stroke.
  • Assessment of putative risk factors including vascular factors, trauma, pregnancies, and infections, stratified by gender.

Main Results:

  • Cervical artery dissection (CeAD) was significantly more common in men (56.7%) than women (43.3%).
  • Men diagnosed with CeAD were older (46.4 years) compared to women (41.0 years).
  • Observed gender differences in risk factors and outcomes were consistent across both CeAD and non-CeAD ischemic stroke groups.

Conclusions:

  • This study confirms a male predominance and older age at dissection for men with CeAD.
  • Gender differences in risk factors may underlie the higher incidence and older age of CeAD in men.
  • The identified risk factors are likely not exclusive to CeAD, suggesting broader implications for cerebrovascular health.