Effect of agonist-antagonist electrical stimulation on muscle afferent recordings in anesthetized rabbits

Objective. Sensory feedback extracted from muscle afferents is an approach to achieve closed-loop control of paralyzed muscles using functional electrical stimulation (FES). The objective of the present study was to characterize the effect of agonist-antagonist electrical stimulation on nerve cuff recordings of muscle afferent activity. Methods. Cuff electrodes were implanted around the tibial and peroneal nerve branches in five acute rabbit experiments. Two wires were implanted in each of the tibialis anterior (TA) and the lateral gastrocnemius (LG) muscles to obtain bipolar, intramuscular stimulation. Electroneurograms (ENG) were recorded during trapezoidal rotations of the ankle joint and compared during periods (25%, 50% and 100% of maximal force) with and without electrical stimulation of the muscle. Results. The activity from a stretched and electrically stimulated muscle showed the same pattern as the recordings from a matched nonstimulated muscle. The background afferent activity increased with increasing level of muscle stimulation. The static and dynamic sensitivities were not found to be different, except in one case (peroneal nerve at 100% TA recruitment). Discussion. The main contribution to the tibial activity was believed to originate from muscle afferents in nonstimulated, synergist muscles. The main contribution to the peroneal activity was believed to be from muscle afferents within the muscle being stimulated. It was suggested that the increased background activity could be attributed to the increased activity of the Golgi tendon organs. Conclusions. Sensory information about joint flexion and joint extension are preserved in muscle afferent recordings from electrically activated muscles at low and intermediate stimulation levels, but it still has to be shown whether muscle afferent information can be useful as sensory feedback in FES control.