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Related Concept Videos

The Evidence for Evolution02:55

The Evidence for Evolution

Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
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Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
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Gap Junctions01:27

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The cytoplasm of adjacent animal cells can exchange small molecules, ions, and secondary messengers via the communication channels which form the gap junctions. These junctions comprise a few hundred to thousands of molecular channels, each made of two halves, called the connexon hemichannel. A connexon is a hexamer of six transmembrane connexin proteins, which assemble radially, thus forming a pore or channel in the center. One connexon hemichannel docks with a corresponding connexon on the...
Gap Junctions01:37

Gap Junctions

Multicellular organisms employ a variety of ways for cells to communicate with each other. Gap junctions are specialized proteins that form pores between neighboring cells in animals, connecting the cytoplasm between the two, and allowing for the exchange of molecules and ions. They are found in a wide range of invertebrate and vertebrate species, mediate numerous functions including cell differentiation and development, and are associated with numerous human diseases, including cardiac and...
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Spanning Openings in Brick Walls

In brick wall construction, supporting structures are crucial for openings like windows and doors to maintain the integrity and support the weight of the wall above. These supports include lintels, corbels, and arches, each serving specific structural purposes.
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Hypothesis: Accept or Fail to Reject?01:17

Hypothesis: Accept or Fail to Reject?

The outcome of any hypothesis testing leads to rejecting or not rejecting the null hypothesis. This decision is taken based on the analysis of the data, an appropriate test statistic, an appropriate confidence level, the critical values, and P-values. However, when the evidence suggests that the null hypothesis cannot be rejected, is it right to say, 'Accept' the null hypothesis?
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Holistic Facial Composite Creation and Subsequent Video Line-up Eyewitness Identification Paradigm
09:49

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Published on: December 24, 2015

[Closing evidence gaps].

Stefan Lange1

  • 1Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen. stefan.lange@iqwig.de

Zeitschrift Fur Evidenz, Fortbildung Und Qualitat Im Gesundheitswesen
|December 14, 2011
PubMed
Summary
This summary is machine-generated.

The Federal Joint Committee (G-BA) and the Institute for Quality and Efficiency in Health Care (IQWiG) face evidence gaps for new medical technologies. Innovative funding is needed to close these gaps and ensure reliable benefit proof.

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Area of Science:

  • Health Services Research
  • Health Technology Assessment
  • Evidence-Based Medicine

Context:

  • The Federal Joint Committee (G-BA) is the primary decision-making body for healthcare services in Germany.
  • The Institute for Quality and Efficiency in Health Care (IQWiG) assesses the benefits of medical interventions.
  • Both organizations frequently encounter 'evidence gaps' where new technologies lack sufficient proof of benefit.

Purpose:

  • To highlight the challenge of evidence gaps in healthcare decision-making.
  • To discuss strategies for addressing these gaps, including negative and conditional coverage decisions.
  • To advocate for innovative funding mechanisms for clinical trials in areas of low commercial interest.

Summary:

  • Evidence gaps arise when new medical technologies enter the healthcare system without robust evidence of their benefits, as assessed by methods of evidence-based medicine.
  • The G-BA and IQWiG face these challenges regularly.
  • Addressing these gaps can involve negative coverage decisions or conditional coverage, but innovative approaches like multilateral research funds are needed to sponsor trials for commercially less attractive interventions.

Impact:

  • Improved decision-making regarding the adoption of new medical technologies.
  • Enhanced patient access to beneficial innovations while mitigating risks of ineffective treatments.
  • Stimulation of research in areas previously neglected due to commercial disincentives.