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The pig: a model for human infectious diseases.

François Meurens¹, Artur Summerfield, Hans Nauwynck

¹Institut National de la Recherche Agronomique, Unité de Recherche 1282, Infectiologie Animale et Santé Publique, 37380, Nouzilly (Tours), France. meurens@tours.inra.fr

Trends in Microbiology

|December 14, 2011

Summary

Domestic pigs offer a superior animal model for studying human infectious diseases due to their physiological similarities to humans. Research in pigs is more predictive of human therapeutic treatments than rodent models, advancing both animal and human health.

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Area of Science:

Comparative Medicine
Infectious Disease Research
Animal Models

Background:

Accurate animal models are crucial for studying human infectious diseases.
Domestic pigs (Sus scrofa domesticus) share significant anatomical, genetic, and physiological similarities with humans.
These similarities make pigs a valuable model for human disease research.

Purpose of the Study:

To review the advantages of using domestic pigs as an animal model for infectious disease research and vaccine development.
To highlight the predictive value of pig models over rodent models for human therapeutic treatments.
To provide examples of human infectious diseases where pig models have advanced knowledge.

Main Methods:

Literature review of studies utilizing pig models for infectious diseases.
Comparative analysis of pig physiology, anatomy, and genetics against human and rodent models.
Case studies illustrating the contribution of pig models to understanding human microbial diseases.

Main Results:

Pigs exhibit a high degree of physiological and anatomical homology with humans, enhancing disease modeling.
Experiments conducted in pigs demonstrate a higher likelihood of predicting therapeutic outcomes in humans compared to rodents.
The use of pig models has led to significant advancements in understanding and treating various human infectious diseases.

Conclusions:

Domestic pigs represent an excellent and highly predictive animal model for human infectious disease research.
The pig model is instrumental in infectious disease research and the development of effective vaccines.
Utilizing pig models contributes valuable knowledge for improving both human and animal health outcomes.