Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Generalization, Discrimination, and Extinction01:24

Generalization, Discrimination, and Extinction

Generalization, discrimination, and extinction are key concepts in operant conditioning that influence how behaviors are learned and maintained.
Generalization occurs when a behavior reinforced in one context is performed in similar situations. For instance, a student who studies diligently for calculus and receives excellent grades might apply the same study habits to psychology and history, expecting similar results. Generalization shows how learning in one setting can influence behavior in...
An Introduction to Free Energy01:05

An Introduction to Free Energy

How can we compare the energy that releases from one reaction to that of another reaction? We use a measurement of free energy to quantitate these energy transfers. Scientists call this free energy Gibbs free energy (abbreviated with the letter G) after Josiah Willard Gibbs, the scientist who developed the measurement. According to the second law of thermodynamics, all energy transfers involve losing some energy in an unusable form such as heat, resulting in entropy. Gibbs free energy...
Gibbs Free Energy02:39

Gibbs Free Energy

One of the challenges of using the second law of thermodynamics to determine if a process is spontaneous is that it requires measurements of the entropy change for the system and the entropy change for the surroundings. An alternative approach involving a new thermodynamic property defined in terms of system properties only was introduced in the late nineteenth century by American mathematician Josiah Willard Gibbs. This new property is called the Gibbs free energy (G) (or simply the free...
Classification of Systems-II01:31

Classification of Systems-II

Continuous-time systems have continuous input and output signals, with time measured continuously. These systems are generally defined by differential or algebraic equations. For instance, in an RC circuit, the relationship between input and output voltage is expressed through a differential equation derived from Ohm's law and the capacitor relation,
Gibbs Free Energy and Thermodynamic Favorability02:23

Gibbs Free Energy and Thermodynamic Favorability

The spontaneity of a process depends upon the temperature of the system. Phase transitions, for example, will proceed spontaneously in one direction or the other depending upon the temperature of the substance in question. Likewise, some chemical reactions can also exhibit temperature-dependent spontaneities. To illustrate this concept, the equation relating free energy change to the enthalpy and entropy changes for the process is considered:
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a deep learning-based tool for coronary artery stenosis evaluation in forensic autopsies using whole slide imaging.

International journal of legal medicine·2026
Same author

Linking dynamic connectivity states to cognitive decline and anatomical changes in Alzheimer's disease.

NeuroImage·2025
Same author

Echoes in AI: Quantifying lack of plot diversity in LLM outputs.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

WP-FSCIL: A Well-Prepared Few-Shot Class-Incremental Learning Framework for Pill Recognition.

IEEE journal of biomedical and health informatics·2025
Same author

Opioid system and related ligands: from the past to future perspectives.

Journal of anesthesia, analgesia and critical care·2024
Same author

Unsupervised Active Visual Search With Monte Carlo Planning Under Uncertain Detections.

IEEE transactions on pattern analysis and machine intelligence·2024

Related Experiment Video

Updated: May 26, 2026

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets
03:37

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets

Published on: March 1, 2024

Free Energy Score Spaces: Using Generative Information in Discriminative Classifiers.

Alessandro Perina1, Marco Cristani, Umberto Castellani

  • 1Microsoft Research, One Microsoft Way, Redmond, WA, USA 98052. alperina@microsoft.com

IEEE Transactions on Pattern Analysis and Machine Intelligence
|December 14, 2011
PubMed
Summary

This study introduces a new Free Energy Score Space (FESS) for machine learning. FESS improves classification performance by leveraging generative models and data

Related Experiment Videos

Last Updated: May 26, 2026

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets
03:37

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets

Published on: March 1, 2024

Area of Science:

  • Machine Learning
  • Data Science
  • Computational Statistics

Background:

  • Generative models can create fixed-dimension feature vectors (score space) from variable-length data samples.
  • Discriminative classifiers perform better in well-chosen score spaces compared to generative or standard feature extractors.

Purpose of the Study:

  • To introduce a novel score space, the Free Energy Score Space (FESS), utilizing the free energy from generative models.
  • To evaluate FESS's effectiveness in improving classification performance.

Main Methods:

  • Developed a new score space by exploiting the free energy associated with a generative model.
  • Classified data using discriminative classifiers optimized within the proposed Free Energy Score Space (FESS).
  • Compared FESS performance against pure generative approaches and hybrid models in computer vision and computational biology.

Main Results:

  • Classifiers optimized in FESS achieve classification performance comparable to or exceeding free energy classifiers.
  • FESS-optimized classifiers demonstrate superior performance over pure generative methods in computer vision and computational biology.
  • The proposed FESS outperforms previous hybrid generative and discriminative model approaches.

Conclusions:

  • The Free Energy Score Space (FESS) offers an effective method for enhancing classification performance.
  • FESS successfully incorporates latent data structures at multiple levels, leading to improved feature representation.
  • This approach provides a significant advancement over existing generative and hybrid modeling techniques.