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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Mitomycin C: biological effects and use in refractive surgery.

Marcony R Santhiago1, Marcelo V Netto, Steven E Wilson

  • 1The Cole Eye Institute, The Cleveland Clinic, Cleveland, OH 44195, USA.

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Mitomycin C (MMC) effectively prevents and treats corneal haze after refractive surgery. While generally safe and effective, optimal parameters and long-term safety require further investigation.

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Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Pharmacology

Background:

  • Corneal haze is a common complication after refractive surgery.
  • Surface ablation techniques have seen a resurgence due to advancements in treatment.
  • Mitomycin C (MMC) is a key therapeutic agent in managing corneal haze.

Purpose of the Study:

  • To review the safety and efficacy of mitomycin C (MMC) as adjuvant therapy in refractive surgery.
  • To explore MMC's role in preventing and treating corneal haze.
  • To assess the impact of MMC on wound healing and corneal cell densities.

Main Methods:

  • Comprehensive literature review.
  • Analysis of studies on MMC's mechanism of action.
  • Evaluation of clinical data on MMC safety and efficacy in refractive surgery.

Main Results:

  • MMC is a potent mitotic inhibitor, effectively reducing keratocyte activation and proliferation.
  • Clinical studies show MMC is safe and effective in preventing and treating corneal haze.
  • Keratocyte density recovers within 6-12 months; endothelial cell density remains stable with standard MMC application.

Conclusions:

  • Mitomycin C (MMC) has proven effective for over a decade in managing corneal haze post-refractive surgery.
  • Further research is needed to establish optimal treatment parameters and long-term safety profiles for MMC.