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The coagulation system of extremely preterm infants: influence of perinatal risk factors on coagulation

C Poralla1, C Traut, H-J Hertfelder

  • 1Department of Neonatology, University of Bonn, Bonn, Germany. christine.poralla@ukb.uni-bonn.de

Journal of Perinatology : Official Journal of the California Perinatal Association
|December 14, 2011
PubMed

Insights

Preterm delivery and perinatal factors affect coagulation in extremely preterm infants. Identifying these risks can help prevent bleeding disorders in newborns.

Area of Science:

  • Neonatal Medicine
  • Hematology
  • Perinatology

Background:

  • The coagulation system's development in extremely preterm infants is not well understood.
  • Preterm delivery and associated risk factors may impact hemostasis.
  • Establishing reference values is crucial for clinical management.

Purpose of the Study:

  • To determine reference values for coagulation system components on day one of life in extremely preterm infants.
  • To investigate the influence of preterm delivery indications on coagulation factor levels.

Main Methods:

  • Retrospective analysis of 132 extremely preterm infants.
  • Coagulation system components were measured.
  • Infants were categorized by preterm delivery cause: maternal indication (A), uteroplacental dysfunction (B), or systemic inflammation (C).

Main Results:

  • Coagulation factor VII and X levels increased with gestational age; fibrinogen, II, V, and VIII remained constant.
  • Factors V and VIII were higher than vitamin K-dependent factors.
  • Infants in groups B and C had lower levels of factors II, VIII, and X compared to group A. Group C showed higher fibrinogen levels than group A.

Conclusions:

  • Perinatal risk factors significantly influence coagulation factor levels in extremely preterm infants.
  • Identifying specific risk factors like placental disorders or chorioamnionitis is important.
  • This knowledge aids in defining infants at risk for bleeding complications.
Abstract

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