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Updated: May 26, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Paroxetine and the electroencephalogram.

E M Sedgwick¹, J Cilasun, J G Edwards

¹Wessex Neurological Centre, Southampton General Hospital, Southampton, SO9 4XY, UK.

Journal of Psychopharmacology (Oxford, England)

|December 14, 2011

Summary

This summary is machine-generated.

Paroxetine treatment showed no significant differences in electroencephalograms (EEG) compared to placebo. EEG recordings revealed no drowsiness or epileptiform activity in either group after 4 weeks.

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Area of Science:

Neuroscience
Psychopharmacology

Background:

Electroencephalograms (EEG) are used to assess brain activity.
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant.

Purpose of the Study:

To evaluate the electroencephalographic (EEG) effects of paroxetine compared to placebo.
To investigate potential EEG changes, including drowsiness and epileptiform activity, associated with paroxetine treatment.

Main Methods:

EEG recordings were obtained from patients before and after 4 weeks of treatment.
Patients received either paroxetine or a placebo.
Assessments were conducted blind to patient, treatment, and treatment interval.

Main Results:

No significant differences in EEG findings were observed between the paroxetine and placebo groups.
No signs of drowsiness or epileptiform activity were detected in either treatment group.

Conclusions:

Four weeks of paroxetine treatment did not produce significant changes in EEG compared to placebo.
Paroxetine does not appear to induce drowsiness or epileptiform activity as assessed by EEG.