Related Experiment Video
Updated: May 26, 2026
Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
Published on: March 11, 2016
Correlation of fundus autofluorescence gray values with vision and microperimetry in resolved central serous
Jaeryung Oh1, Seong-Woo Kim, Soon-Sun Kwon
1Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
Purpose:
To evaluate the prognostic value of grayscale parameters in fundus autofluorescence (FAF) for visual function in resolved central serous chorioretinopathy (CSC).
Methods:
Seventy-six eyes of 67 patients with CSC that had been resolved for more than 4 months were analyzed retrospectively. Both the short-wavelength (SW)-FAF and near infrared (NIR)-FAF gray value parameters, including the mean, standard deviation, and coefficient of variation (CV), were calculated at 350-μm- and 1200-μm-diameter circles centered on the fovea. The FAF gray value parameters correlated with -logMAR best corrected visual acuity (BCVA) and mean microperimetry (MP) at the 2° and 4° diameters from the foveal center.
Results:
The mean -logMAR BCVA was 0.15 ± 0.23. The mean MP was 12.87 ± 3.79 dB at 2° and 13.54 ± 3.37 dB at 4°. The -logMAR BCVA correlated most strongly with the mean SW-FAF gray value at the 350-μm circle centered around the fovea (SW-M350; ρ = 0.353; P = 0.002), and the SD of the SW-FAF gray value at the 350-μm circle centered around the fovea (SW-SD350) correlated most strongly with the MP at 2° (ρ = -0.416, P < 0.0001) and 4° (ρ = -0.435, P < 0.0001). The NIR-FAF gray value parameters did not correlate with the macular function tests.
Conclusions:
In subjects with resolved CSC, FAF gray values correlated with visual function. BCVA correlated most strongly with SW-M350. MP at 2° and at 4° correlated most strongly with SW-SD350.
