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Related Concept Videos

Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
Nucleic acids02:43

Nucleic acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
Nucleic Acids02:43

Nucleic Acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
Nucleic Acids02:43

Nucleic Acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
Nucleic Acids02:43

Nucleic Acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
Nucleic Acids and Nucleotides01:20

Nucleic Acids and Nucleotides

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
Deoxyribonucleic Acid (DNA)
DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and the organelles such as chloroplasts and mitochondria. In...

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Updated: May 26, 2026

Probing The Structure And Dynamics Of Nucleosomes Using Atomic Force Microscopy Imaging
09:52

Probing The Structure And Dynamics Of Nucleosomes Using Atomic Force Microscopy Imaging

Published on: January 31, 2019

Structure and dynamics of nucleic acids.

Ivan Krstić1, Burkhard Endeward, Dominik Margraf

  • 1Goethe University Frankfurt, Frankfurt am Main, Germany.

Topics in Current Chemistry
|December 14, 2011
PubMed
Summary
This summary is machine-generated.

Electron Paramagnetic Resonance (EPR) methods reveal structural and dynamic properties of DNA and RNA. Dipolar spectroscopy advances understanding of nucleic acid interactions with molecules and proteins.

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Last Updated: May 26, 2026

Probing The Structure And Dynamics Of Nucleosomes Using Atomic Force Microscopy Imaging
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Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
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Published on: March 1, 2022

Area of Science:

  • Biophysics
  • Structural Biology
  • Molecular Biophysics

Background:

  • Nucleic acids (RNA and DNA) are fundamental to life, with their structure and dynamics influencing biological function.
  • Understanding molecular interactions involving nucleic acids is crucial for drug discovery and molecular biology.

Purpose of the Study:

  • To detail the application of continuous-wave (CW) and pulsed Electron Paramagnetic Resonance (EPR) techniques.
  • To explore the structural and dynamical characteristics of RNA and DNA.
  • To investigate the interactions between nucleic acids and small molecules or proteins.

Main Methods:

  • Continuous-wave (CW) Electron Paramagnetic Resonance (EPR) spectroscopy.
  • Pulsed Electron Paramagnetic Resonance (EPR) spectroscopy.
  • Dipolar spectroscopy for nucleic acid analysis.

Main Results:

  • Demonstration of CW and pulsed EPR for probing nucleic acid structure.
  • Characterization of nucleic acid dynamics using EPR.
  • Insights into the interaction mechanisms between nucleic acids and other molecules.

Conclusions:

  • EPR spectroscopy is a powerful tool for elucidating nucleic acid properties.
  • Dipolar spectroscopy offers advanced capabilities for studying nucleic acid systems.
  • This chapter provides a comprehensive overview of EPR applications in nucleic acid research.