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Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer
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Adenocarcinoma in pulmonary sequestration.

Lukman Lawal1, Dimitrios Mikroulis, Savvas Eleftheriadis

  • 1Department of Cardiothoracic Surgery, University Hospital, Alexandroupolis, Greece. lawal@in.gr

Asian Cardiovascular & Thoracic Annals
|December 14, 2011
PubMed
Summary

A rare case of lung adenocarcinoma was found in a patient with intralobar sequestration, a congenital lung abnormality. This highlights the importance of considering rare diagnoses in patients with persistent respiratory symptoms.

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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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11:17

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Published on: September 20, 2016

Area of Science:

  • Pulmonology
  • Thoracic Surgery
  • Oncology

Background:

  • Intralobar pulmonary sequestration is a rare congenital lung malformation.
  • Lung cancer is a common malignancy, but rarely associated with sequestration.

Observation:

  • A 67-year-old male smoker presented with hemoptysis and recurrent pneumonia.
  • Chest CT revealed an emphysematous cyst and air-fluid level cavities in the left lower lobe.

Findings:

  • Intraoperative finding during left lower lobectomy was intralobar sequestration.
  • Histopathology confirmed adenocarcinoma within the sequestrated lobe.
  • This represents one of only eight reported cases of lung cancer and sequestration since 1963.

Implications:

  • This case underscores the importance of thorough histopathological examination in diagnosing rare pulmonary conditions.
  • Highlights the need for considering malignancy in congenital lung abnormalities presenting with atypical symptoms.
  • Contributes to the limited literature on the co-occurrence of lung cancer and pulmonary sequestration.