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Updated: May 26, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
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Published on: March 24, 2015

Interferon alpha for chronic hepatitis D.

Zaigham Abbas1, Muhammad Arsalan Khan, Mohammad Salih

  • 1Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Diwan Complex, Chand Bibi Road, Karachi, Sindh, Pakistan.

The Cochrane Database of Systematic Reviews
|December 14, 2011
PubMed
Summary
This summary is machine-generated.

Interferon alpha shows limited efficacy for treating Hepatitis D virus (HDV) infection, with no sustained viral response in most patients. High risk of bias necessitates further large-scale randomized trials to confirm benefits and harms.

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Area of Science:

  • Hepatology
  • Virology
  • Clinical Trials

Background:

  • Hepatitis D virus (HDV) is a defective RNA virus requiring Hepatitis B virus (HBV) coinfection.
  • HDV infection presents significant treatment challenges.
  • Existing data on interferon alpha efficacy for HDV is limited, particularly from randomized trials.

Purpose of the Study:

  • To evaluate the efficacy and safety of interferon alpha in patients with chronic Hepatitis D.
  • To synthesize evidence from randomized clinical trials on interferon alpha treatment for HDV.

Main Methods:

  • Systematic review and meta-analysis of randomized clinical trials.
  • Searches conducted across multiple databases (Cochrane, MEDLINE, EMBASE) up to May 2011.
  • Data extraction included mortality, virologic, biochemical, histological response, and adverse events.

Main Results:

  • Six trials with 201 participants were included; all had high risk of bias.
  • Interferon alpha showed no significant benefit in sustained virologic response (82.6% failure vs. 94.8% in controls).
  • Adverse events were common and sometimes severe, including flu-like symptoms and hematologic abnormalities.

Conclusions:

  • Interferon alpha does not appear to cure Hepatitis D and its benefits are not sustained in most patients.
  • High risk of bias and random error limits definitive conclusions.
  • Further large-scale, low-bias randomized trials are required to establish interferon alpha's role in HDV treatment.