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High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

Fast cardiac T1 mapping in mice using a model-based compressed sensing method.

Wen Li¹, Mark Griswold, Xin Yu

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, United States of America.

Magnetic Resonance in Medicine

|December 14, 2011

Summary

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This study introduces a fast cardiac T1 mapping technique using model-based compressed sensing for small animals. This method enables rapid, high-resolution T1 measurement of the mouse heart, improving diagnostic capabilities.

Area of Science:

Biomedical Imaging
Magnetic Resonance Imaging (MRI)
Quantitative Physiology

Background:

Longitudinal relaxation time (T1) mapping offers objective diagnostic information.
Current T1 mapping techniques are often time-consuming, limiting their clinical and research applications.

Purpose of the Study:

To develop and validate a model-based compressed sensing method for rapid cardiac T1 mapping in small animals.
To achieve high spatial resolution T1 maps of the mouse heart efficiently.

Main Methods:

A model-based compressed sensing approach was employed, exploiting signal sparsity in the T1 recovery direction to reconstruct under-sampled data.
Simulations were conducted to assess reconstruction accuracy under diverse conditions.
Phantom and in vivo studies in mice, including manganese-enhanced MRI, were performed for validation.

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Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery (SALLI) MRI in Rats

Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery (SALLI) MRI in Rats

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Last Updated: May 26, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

Optical Mapping of Action Potentials and Calcium Transients in the Mouse Heart

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Published on: September 13, 2011

Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery (SALLI) MRI in Rats

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Published on: July 19, 2013

Main Results:

The compressed sensing method successfully removed aliasing artifacts from under-sampled cardiac images.
Accurate reconstruction of T1 maps was achieved in simulations, phantoms, and in vivo mouse studies.
Fast T1 mapping (<80 seconds) of the mouse heart at high spatial resolution (234×469 µm²) was demonstrated.

Conclusions:

Model-based compressed sensing enables rapid and accurate cardiac T1 mapping in small animals.
This technique significantly reduces scan time while maintaining high spatial resolution.
The method holds promise for advancing quantitative cardiovascular research in preclinical models.