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Updated: May 26, 2026
19:57
An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
Published on: March 30, 2014
Drug resistance in HIV-1
1Division of Infectious Diseases, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA. dkuritzkes@partners.org
Current Opinion in Virology
|December 14, 2011
Summary
Newer antiretroviral drugs effectively treat multidrug-resistant human immunodeficiency virus type 1 (HIV-1). However, novel drug resistance mutations can emerge, potentially limiting treatment effectiveness.
Area of Science:
- Virology
- Infectious Diseases
- Pharmacology
Background:
- Antiretroviral drug resistance patterns in HIV-1 are evolving due to changes in treatment regimens.
- The introduction of novel antiretroviral drugs has significantly impacted HIV-1 management.
Purpose of the Study:
- To review recent information on antiretroviral drug resistance in human immunodeficiency virus type 1 (HIV-1).
- To summarize the impact of changing antiretroviral regimens on HIV-1 drug resistance patterns.
Main Methods:
- Literature review of recent studies on antiretroviral drug resistance.
- Analysis of changes in resistance mutation prevalence associated with specific drug classes.
Main Results:
- Thymidine analog resistance mutations are less common with the shift to tenofovir and abacavir.
- Protease inhibitor (PI) resistance mutations are infrequent with the widespread use of ritonavir-boosted PIs.
- Novel drug classes (integrase inhibitors, CCR5 antagonists) have improved treatment of multidrug-resistant HIV-1, but new resistance mutations are emerging.
Conclusions:
- Newer antiretroviral agents offer effective treatment options for multidrug-resistant HIV-1.
- Emergence of novel drug resistance mutations can compromise the long-term efficacy of current and future HIV-1 therapies.
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