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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

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Updated: May 26, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

Nodular cutaneous amyloidosis.

Jessica Borowicz1, Leah Shama, Richard Miller

  • 1Largo Medical Center, Largo, FL, USA. drjflowers@hotmail.com

Skinmed
|December 15, 2011
PubMed
Summary
This summary is machine-generated.

Nodular cutaneous amyloidosis (NCA) is a rare skin condition characterized by amyloid deposits in the skin. This case highlights its progressive and disfiguring nature, emphasizing the need for ongoing monitoring for systemic involvement.

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Area of Science:

  • Dermatology
  • Pathology
  • Oncology

Background:

  • Nodular cutaneous amyloidosis (NCA) is a rare form of localized amyloidosis.
  • It is characterized by the deposition of amyloid protein in the skin, often presenting as papules or nodules.
  • While typically localized, monitoring for systemic involvement is crucial.

Observation:

  • A 56-year-old man presented with a rapidly developing, irritated, and bleeding lesion on his shoulder.
  • Physical examination revealed a raised, friable, yellow-pink waxy plaque.
  • Biopsy confirmed nodular cutaneous amyloidosis (amyloid light-type) with kappa light chain restriction.

Findings:

  • Initial work-up, including extensive laboratory tests and imaging, did not reveal systemic amyloidosis.
  • Over two years, the patient developed multiple painful, disfiguring lesions on his trunk, consistent with progressive NCA.
  • Despite initial localization, the disease demonstrated significant progression and morbidity.

Implications:

  • This case underscores the potential for nodular cutaneous amyloidosis to progress and cause significant disfigurement and pain.
  • It highlights the importance of comprehensive initial work-up to rule out systemic disease.
  • Long-term monitoring is essential for early detection of systemic progression, and novel treatment modalities like CO2 laser ablation may be considered for symptomatic relief.