Related Experiment Video
Updated: May 26, 2026
07:54
Accessing the Subdural Space of the Rodent Spinal Cord for Treatment Delivery
Published on: August 8, 2025
An anatomical study of the intradural space
C B Collier1, M A Reina, A Prats-Galino
1Department of Clinical Medical Sciences and Applied Molecular Medicine Institute, CEU San Pablo University School of Medicine, Madrid, Spain. nfi1@pacific.net.au
Anaesthesia and Intensive Care
|December 15, 2011
Summary
Accidental epidural needle insertion can create intradural spaces. This may explain unusual, life-threatening neuraxial block complications and associated imaging findings in patients.
Area of Science:
- Anesthesiology
- Neurosurgery
- Anatomy
Background:
- Epidural blocks carry risks, including potential needle or catheter misplacement.
- Accidental dural puncture can lead to unexpected neuraxial block complications.
Purpose of the Study:
- To investigate the possibility of creating intradural spaces within the dura mater during epidural procedures.
- To explore the anatomical basis for accidental intradural catheterization.
Main Methods:
- Human thoraco-lumbar dura samples were analyzed using scanning electron microscopy.
- Attempts were made to insert epidural catheters into the dura under optical microscopy.
Main Results:
- Electron microscopy revealed spaces between the concentric laminae of the dura.
- Epidural catheters were successfully inserted into the dura, creating persistent intradural spaces in 8 of 32 specimens.
Conclusions:
- The dura mater may contain spaces that can be accessed by epidural needles or catheters.
- This anatomical possibility could explain atypical neuraxial blocks and related radiological findings.
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