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Updated: May 26, 2026
Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
Synthesis of bioactive 28-hydroxy-3-oxolup-20(29)-en-30-al with antileukemic activity
Pranab Ghosh1, Amitava Mandal, Joydip Ghosh
1Natural Product and Polymer Chemistry Laboratory, Department of Chemistry, University of North Bengal, Darjeeling, West Bengal, India. pizy12@yahoo.com
Abstract:
An easy and efficient route to partial synthesis of bioactive 28-hydroxy-3-oxolup-20(29)-en-30-al (1), starting from betulinic acid (2), has been developed (eight steps, 44% overall yield). Structures of all the compounds were determined by spectral studies (IR, (1)H, (13)C NMR, MS, NOESY, COSY, etc.). Compound 1 and the precursors (2, 3, 5, and 7) showed antiproliferative activities against human K562 leukemia, murine WEHI3 leukemia, and murine MEL erythroid progenitor.
