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Updated: May 26, 2026

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
09:54

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

Serotonergic action on dorsal striatal function.

Brian N Mathur1, David M Lovinger

  • 1Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Rockville, MD 20852-9411, USA.

Parkinsonism & Related Disorders
|December 15, 2011
PubMed
Summary
This summary is machine-generated.

Serotonin (5-HT) influences the striatum, a brain region vital for movement. This review explores its role in Parkinson's disease and L-DOPA-induced dyskinesia, aiding understanding of these conditions.

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Published on: January 12, 2012

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Last Updated: May 26, 2026

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
09:54

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry
08:49

Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry

Published on: January 12, 2012

Area of Science:

  • Neuroscience
  • Neuropharmacology
  • Movement Disorders

Background:

  • Serotonin (5-HT) is a key neurotransmitter affecting brain function.
  • The serotonergic system is linked to neuropsychiatric disorders like Parkinson's disease and L-DOPA-induced dyskinesia.
  • Striatal dysfunction is central to these movement disorders.

Purpose of the Study:

  • To review the literature on serotonergic effects on dorsal striatal function.
  • To discuss the role of the striatal serotonergic system in physiological and parkinsonian states.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of serotonergic pathways and receptor actions in the dorsal striatum.

Main Results:

  • Serotonin (5-HT) modulates dorsal striatal function through diverse receptors.
  • The dorsal raphe nucleus releases 5-HT into the dorsal striatum, impacting pre- and postsynaptic components.

Conclusions:

  • The striatal serotonergic system plays a significant role in motor control and action learning.
  • Understanding these roles is crucial for developing treatments for Parkinson's disease and related conditions.