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Effect of antenatal iodinated contrast agent on neonatal thyroid function

S Rajaram1, C E Exley, F Fairlie

  • 1Department of Radiology, Sheffield Teaching Hospital Trust, Sheffield, UK. smitha.rajaram@sth.nhs.uk

The British Journal of Radiology
|December 15, 2011
PubMed

Insights

Exposure to iodinated contrast media during pregnancy for CT pulmonary angiography (CTPA) did not affect neonatal thyroid function. Thyroid tests were normal in infants whose mothers received contrast versus those who did not.

Area of Science:

  • Radiology
  • Neonatal Medicine
  • Endocrinology

Background:

  • Pulmonary embolism in pregnancy requires accurate diagnosis.
  • Computed tomography pulmonary angiography (CTPA) with iodinated contrast media is a common diagnostic tool.
  • The safety of in utero exposure to iodinated contrast media on neonatal thyroid function requires evaluation.

Purpose of the Study:

  • To evaluate the impact of maternal exposure to iodinated contrast media during CTPA on neonatal thyroid function.
  • To compare thyroid function in neonates exposed in utero to iodinated contrast media with a control group.

Main Methods:

  • Retrospective review of 115 pregnant patients investigated for pulmonary embolism.
  • Group A: 73 pregnant patients who underwent CTPA with iodinated contrast.
  • Group B (control): 42 pregnant patients who underwent perfusion imaging only.
  • Comparison of neonatal thyroid function tests between the two groups.

Main Results:

  • All neonatal thyroid function tests were within normal limits for both groups.
  • No statistically significant difference in thyroid function was observed between neonates exposed to iodinated contrast media in utero and the control group.

Conclusions:

  • In utero exposure to iodinated contrast media via maternal CTPA does not appear to adversely affect neonatal thyroid function.
  • Results should be interpreted with caution due to the small patient cohort size.
Abstract

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