Related Experiment Video

Updated: May 26, 2026

Retroperitoneal Laparoscopic Debridement and Drainage for Pancreatic Abscess
03:42

Retroperitoneal Laparoscopic Debridement and Drainage for Pancreatic Abscess

Published on: March 15, 2024

[Antibacterial therapy of severe intra-abdominal infections]

V V Boĭko, Iu V Ivanova

    Klinichna Khirurhiia
    |December 16, 2011
    PubMed

    Insights

    Meropenem (Mepenam) effectively treats severe intra-abdominal infections when used as empirical therapy. This study evaluated its efficacy and patient outcomes, providing treatment recommendations.

    Area of Science:

    • Infectious Diseases
    • Pharmacology
    • Surgical Infections

    Background:

    • Severe intra-abdominal infections pose significant treatment challenges.
    • Empirical antibiotic therapy is crucial for initial management.
    • Meropenem is a broad-spectrum carbapenem antibiotic.

    Purpose of the Study:

    • To evaluate the efficacy of meropenem (Mepenam) as empirical therapy.
    • To assess disease outcomes in patients with severe intra-abdominal infections.
    • To provide clinical recommendations for meropenem use.

    Main Methods:

    • Retrospective analysis of patient data.
    • Assessment of clinical outcomes and microbiological data.
    • Evaluation of meropenem (Mepenam) efficacy and safety.

    Main Results:

    • Meropenem demonstrated significant efficacy in treating severe intra-abdominal infections.
    • Positive patient outcomes were observed with empirical meropenem use.
    • The preparation showed a favorable safety profile.

    Conclusions:

    • Meropenem (Mepenam) is a valuable option for empirical treatment of severe intra-abdominal infections.
    • Clinical experience supports its use in managing these complex infections.
    • Recommendations for optimized meropenem application are provided.

    Related Concept Videos

    Acute Pyelonephritis II: Diagnostic Studies and Management01:28

    Acute Pyelonephritis II: Diagnostic Studies and Management

    Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
    Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

    Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

    Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
    Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

    Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

    A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
    Inflammatory Bowel Disease IV: Pharmacological Management01:29

    Inflammatory Bowel Disease IV: Pharmacological Management

    Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
    Pharmacologic...
    Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

    Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

    Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
    Urinary Tract Infection IV: Nursing Management01:17

    Urinary Tract Infection IV: Nursing Management

    In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs like...