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Related Concept Videos

Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Esophageal Achalasia01:27

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Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...
Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...

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Related Experiment Video

Updated: May 26, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

[Eosinophilic oesophagitis].

Øyvind Holme1, Erling Tjora, Lars Aabakken

  • 1Medisinsk avdeling, Sørlandet sykehus Kristiansand, og Det medisinske fakultet, Universitetet i Oslo, Norway. oyvind.holme@sshf.no

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|December 16, 2011
PubMed
Summary
This summary is machine-generated.

Eosinophilic oesophagitis (EoE) is a chronic esophageal inflammatory disease increasingly diagnosed in children and adults. Early diagnosis and treatment, including dietary changes or corticosteroids, improve outcomes and prevent complications.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Allergy

Context:

  • Eosinophilic oesophagitis (EoE) is a chronic esophageal inflammatory condition.
  • Increasing awareness has led to more frequent diagnoses in children and adults.
  • It is a common cause of esophageal dysfunction.

Purpose:

  • To review the current understanding of eosinophilic oesophagitis.
  • To highlight diagnostic criteria and treatment options.
  • To emphasize the importance of recognizing this condition.

Summary:

  • EoE is increasingly diagnosed, particularly in Western countries, affecting males more than females.
  • Common symptoms include dysphagia, food impaction, eating problems, abdominal pain, and growth issues.
  • Diagnosis relies on clinical presentation, endoscopy, and esophageal mucosal eosinophils, often linked to allergic reactions.

Impact:

  • Increased diagnosis may reflect higher prevalence or improved physician awareness.
  • Prompt diagnosis and management can lead to good outcomes.
  • Effective treatment can prevent serious complications like esophageal strictures and food impaction.