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Related Experiment Videos

Heparin-associated skin necrosis.

J Fowlie1, P D Stanton, J R Anderson

  • 1Department of Surgery, Glasgow Royal Infirmary, UK.

Postgraduate Medical Journal
|July 1, 1990
PubMed
Summary

Skin necrosis from subcutaneous heparin injections can precede heparin-induced thrombocytopenia and pulmonary embolism. This sequence of adverse events associated with heparin is not rare.

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Area of Science:

  • Medicine
  • Pharmacology
  • Dermatology

Background:

  • Subcutaneous heparin is widely used for anticoagulation.
  • Adverse reactions to heparin can occur, including skin complications.

Observation:

  • A case presented with skin necrosis at heparin injection sites.
  • The patient subsequently developed heparin-induced thrombocytopenia and pulmonary embolism.

Findings:

  • Heparin-associated skin necrosis is a recognized complication.
  • This complication can be an early sign of more severe systemic heparin reactions.

Implications:

  • Clinicians should be vigilant for skin necrosis following heparin administration.
  • Early recognition may allow for timely intervention to prevent serious thrombotic events.
  • Consider heparin-induced thrombocytopenia in patients with skin necrosis and thrombosis.