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[Role of (pro)renin receptor in diabetic retinopathy]

Shingo Satofuka1

  • 1Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan. satofuka@med.teikyo-u.ac.jp

Nippon Ganka Gakkai Zasshi
|December 17, 2011
PubMed

Insights

The newly discovered (pro)renin receptor activates tissue renin-angiotensin system (RAS) and other signaling pathways. This receptor-associated prorenin system (RAPS) is linked to diabetic retinopathy, offering a new therapeutic target.

Area of Science:

  • Endocrinology and Molecular Biology
  • Cardiovascular Physiology

Context:

  • The renin-angiotensin system (RAS) regulates blood pressure, but its tissue-specific activation mechanisms remain unclear.
  • Organ damage is linked to activated tissue RAS, necessitating a deeper understanding of its molecular underpinnings.

Purpose:

  • To elucidate the pathogenic mechanism of tissue RAS activation.
  • To introduce the nomenclature receptor-associated prorenin system (RAPS) for pathways involving the (pro)renin receptor.
  • To explore the role of RAPS in diabetes-induced retinal inflammation.

Summary:

  • The (pro)renin receptor activates both the tissue RAS and RAS-independent intracellular signaling pathways.
  • Prorenin binding to its receptor triggers these dual activation mechanisms.
  • The receptor-associated prorenin system (RAPS) encompasses these two major signaling cascades.

Impact:

  • The discovery of the (pro)renin receptor clarifies a key mechanism in tissue RAS activation.
  • RAPS provides a framework for understanding prorenin's diverse signaling roles.
  • The association of RAPS with diabetic retinopathy suggests the (pro)renin receptor as a potential therapeutic target for this condition.

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