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Updated: May 26, 2026

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
Published on: May 26, 2023
Surgical management of mitral valve infective endocarditis
Charles F Evans1, James S Gammie
1Division of Cardiac Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Abstract:
Active mitral valve infective endocarditis is a challenging clinical problem with a high rate of mortality. Surgery is currently performed in more than 40% of patients, and selecting those patients who will benefit from surgical intervention and performing a technically sound operation at the proper time are keys to optimizing outcomes. Moderate-to-severe and severe mitral regurgitation, large, mobile vegetations, paravalvular abscess, embolic events, failure of antibiotic therapy, and infection with a fungal organism are indications for prompt operation. The use of computed tomography imaging is important to determine whether there are noncardiac sources of infection, and transesophageal echocardiography is essential to delineate valvular dysfunction, identify paravalvular abscesses, rule out involvement of other valves, and plan operative therapy. In most cases, surgery should not be delayed because of cerebrovascular emboli. Mitral valve repair is favored over replacement whenever possible, is associated with superior short- and long-term outcomes, and should be possible in most cases. Operative mortality is <10% and 5-year survival is >80%.
Insights
Active mitral valve infective endocarditis requires timely surgical intervention for better outcomes. Mitral valve repair is preferred over replacement, offering superior results and high survival rates.
Area of Science:
- Cardiology
- Infectious Diseases
- Cardiac Surgery
Background:
- Active mitral valve infective endocarditis presents significant mortality risks.
- Surgical intervention is necessary for over 40% of patients.
- Optimal timing and patient selection are crucial for surgical success.
Purpose of the Study:
- To outline indications for prompt surgical intervention in mitral valve infective endocarditis.
- To emphasize the role of imaging in surgical planning.
- To highlight the benefits of mitral valve repair over replacement.
Main Methods:
- Review of clinical indications for surgery.
- Importance of computed tomography (CT) for noncardiac infection sources.
- Essential role of transesophageal echocardiography (TEE) for valvular assessment and surgical planning.
Main Results:
- Indications for surgery include severe regurgitation, large vegetations, abscess, emboli, and fungal infection.
- TEE is vital for delineating valve dysfunction and planning operative therapy.
- Mitral valve repair yields superior outcomes compared to replacement.
- Operative mortality is less than 10%, with 5-year survival exceeding 80%.
Conclusions:
- Prompt surgical intervention is key for managing active mitral valve infective endocarditis.
- Mitral valve repair should be prioritized for improved patient outcomes.
- Effective use of imaging modalities enhances surgical decision-making and planning.
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