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Updated: May 26, 2026
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
Exploration on surgical-related factors influencing HCC patients prognosis
Zhou Lei1, Liu Chang, Meng Fan-Di
1Department of Hepatobiliary Surgery, The First Affiliated Hospital, Xi'an Jiao Tong University, Xi'an, China.
Background/Aims:
To evaluate the prognostic value of surgical operation-related factors in patients with primary liver cancer (PLC).
Methodology:
A retrospective study was carried out analyzing the data of 114 patients with PLC undergoing hepatic resection from January 2002 to December 2009. Survival rates were analyzed using Kaplan-Meier curve and log-rank tests were employed to compare the survival rates observed in those patients with surgical operation-related factors (e.g. operation method, time, portal blockage, complications, resection margin, amount of intraoperative blood loss and amount of blood transfusion), and bivariate correlation analysis was used to examine the associations of these surgical operation-related factors.
Results:
Intraoperative blood loss, amount of blood transfusion and operation time were significant predictors for patients with PLC after hepatic resection (p<0.05). The operation method, resection margin, portal blockage and complications (e.g. intra-abdominal infections, intra-abdominal hemorrhage, gastro-intestinal hemorrhage, biliary leakage, etc.) were not significant prognostic factors (p>0.05). There was a positive correlation between intraoperative blood loss, amount of blood transfusion, portal blockage time and operation time, in addition, a negative correlation was found between resection margin and the operation method.
Conclusions:
Hepatic surgery can improve the patients prognosis if the operation time is shortened, and the amount of intraoperative blood transfusion and blood loss lessened.
