Circadian rhythm disturbances in neurological patients with chronic hypothermia

1) We investigated the circadian rhythms of BT and sleep-wakefulness in 8 neurological patients who showed chronic low BT. Their etiologies were varied. 2) Their thyroid functions were normal, but their hypothalamic functions were disturbed endocrinologically to various degrees. 3) Their temperature-elevation system was able to function when they suffered from infectious disease. 4) Six patients had circadian rhythm disturbances of BT and sleep-wakefulness. This fact suggests that there is a close relationship of BT regulation and control of its rhythm, and also a close association of 2 pacemakers, namely, that of sleep-wakefulness and that of BT.