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Updated: May 26, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
A motor signature of REM sleep behavior disorder
Delphine Oudiette1, Smaranda Leu-Semenescu, Emmanuel Roze
1Sleep Disorders Unit, Pitié-Salpêtrière Hospital, APHP, Paris, France.
Background:
The purpose of this study was to determine if there was a common pattern in movements during REM sleep behavior disorder (RBD).
Methods:
We blindly compared video-monitored movements during RBD (n = 136 clips) and wakefulness/arousal (n = 53 clips) in patients with Parkinson's disease (n = 29) and without parkinsonism (idiopathic RBD, n = 31; narcolepsy, n = 5).
Results:
The scorers accurately guessed the sleep/wake stage of 94% of video clips. Compared with wake movements, RBD movements were faster and more often repeated, jerky, and pseudohallucinatory, not self-centered, never associated with tremor, and rarely involved the environment in an appropriate manner. A specific posture of the hand (limp wrist with flexed digits) during grasping movements was evidenced during RBD in 48% of patients, reminiscent of hand-babbling in babies.
Conclusions:
These characteristics of movements were found in the 3 conditions (Parkinson's disease, idiopathic RBD, and primary narcolepsy), delineating a common motor signature of RBD.
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