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Related Experiment Video

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A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

Ghrelin and cardiovascular diseases.

Ichiro Kishimoto¹, Takeshi Tokudome, Hiroshi Hosoda

¹National Cardiovascular Center Research Institute, Osaka, Japan. kishimot@hsp.ncvc.go.jp

Journal of Cardiology

|December 20, 2011

Summary

Ghrelin, a peptide discovered in 1999, shows promise for treating cardiovascular diseases. Studies indicate ghrelin administration improves cardiac function and reduces mortality in conditions like heart failure and myocardial infarction.

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Area of Science:

Endocrinology
Cardiology
Physiology

Background:

Ghrelin, a stomach-derived peptide, was identified in 1999.
Initially recognized for its growth hormone-releasing and orexigenic effects.
Emerging evidence suggests potential benefits in cardiovascular diseases.

Purpose of the Study:

To explore the therapeutic potential of ghrelin in cardiovascular conditions.
To investigate ghrelin's effects on cardiac function, remodeling, and mortality.
To elucidate the mechanisms underlying ghrelin's cardiovascular actions.

Main Methods:

Administration of ghrelin in animal models of chronic heart failure and myocardial infarction.
Assessment of cardiac function, cardiac remodeling, and survival rates.
Exploration of potential mediating pathways including growth hormone, energy balance, direct cellular effects, and autonomic nervous system regulation.

Main Results:

Ghrelin administration improved cardiac function and remodeling in chronic heart failure.
Early post-infarction ghrelin treatment reduced fatal arrhythmias and mortality in a myocardial infarction model.
Evidence suggests central mechanisms involving decreased sympathetic nervous system activity.

Conclusions:

Ghrelin demonstrates significant therapeutic potential for acute myocardial infarction and chronic heart failure.
Cardiovascular benefits may stem from a combination of hormonal, metabolic, direct cellular, and neural effects.
Ghrelin's ability to modulate the sympathetic nervous system offers a unique therapeutic avenue for cardiovascular diseases.