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Updated: May 26, 2026
07:55
Ex Vivo Organotypic Corneal Model of Acute Epithelial Herpes Simplex Virus Type I Infection
Published on: November 3, 2012
Multiple parallel-line endotheliitis--a form of herpes simplex keratitis?
1Department of Ophthalmology, St James' University Hospital, Leeds, UK.
Summary
This case report suggests multiple parallel-line endotheliitis may be a mild form of herpes simplex keratitis. The condition responded well to steroid treatment, indicating a significant immune response.
Area of Science:
- Ophthalmology
- Virology
Background:
- Multiple parallel-line endotheliitis is an uncommon corneal condition.
- Herpes simplex virus (HSV) is a common cause of infectious keratitis.
Observation:
- An 89-year-old woman presented with decreased vision and corneal edema with characteristic "railroad track" keratic precipitates.
- The patient had positive serological titers for herpes simplex virus (HSV).
Findings:
- The patient's condition, multiple parallel-line endotheliitis, showed a significant positive response to topical corticosteroid therapy.
- The presentation and response suggest a potential link between this endotheliitis pattern and HSV infection.
Implications:
- Multiple parallel-line endotheliitis could be a manifestation of herpes simplex keratitis.
- The condition's sensitivity to steroids highlights the role of immune mechanisms in its pathogenesis.
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