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Related Experiment Video

Updated: May 26, 2026

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging
13:49

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

Published on: January 11, 2011

Nanowire-based single-cell endoscopy.

Ruoxue Yan1, Ji-Ho Park, Yeonho Choi

  • 1Department of Chemistry, University of California, and Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

Nature Nanotechnology
|December 20, 2011
PubMed
Summary
This summary is machine-generated.

Researchers developed a nanowire optical fiber probe for intracellular light delivery and detection. This novel tool enables precise gene/drug delivery and biosensing within living cells without causing toxicity.

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Last Updated: May 26, 2026

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Area of Science:

  • Nanotechnology
  • Cell Biology
  • Optical Engineering

Background:

  • One-dimensional smart probes like nanowires and nanotubes offer potential for cellular applications.
  • Existing probes face limitations in subwavelength optical communication across cell membranes.
  • Intracellular manipulation and sensing require advanced tools for spatial and temporal precision.

Purpose of the Study:

  • To demonstrate a nanowire waveguide on an optical fiber tip for intracellular optical communication.
  • To investigate the probe's capability for payload delivery and subcellular signal detection.
  • To assess the biocompatibility and safety of the probe within living mammalian cells.

Main Methods:

  • Fabrication of a nanowire waveguide attached to a tapered optical fiber tip.
  • Guiding visible light for intracellular delivery and signal detection in mammalian cells.
  • Evaluating payload delivery using light-activated mechanisms and assessing cellular toxicity.

Main Results:

  • The nanowire probe successfully guided visible light into intracellular compartments.
  • High-resolution optical signal detection from subcellular regions was achieved.
  • Light-activated payload delivery with spatial and temporal specificity was demonstrated.
  • No significant cellular toxicity was observed upon probe insertion and illumination.

Conclusions:

  • The developed nanowire optical fiber probe is a viable tool for intracellular optical communication.
  • This technology enables precise, non-toxic gene/drug delivery and biosensing within living cells.
  • The probe offers a new platform for high-resolution intracellular imaging and manipulation.