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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...

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Related Experiment Video

Updated: May 26, 2026

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
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Wnt transmembrane signaling and long-term spatial memory.

Nino Tabatadze1, Caroline Tomas, Rhona McGonigal

  • 1Department of Psychology, Northwestern University, 2029 Sheridan Rd., Evanston, IL 60208, USA.

Hippocampus
|December 20, 2011
PubMed
Summary

Wnt signaling, crucial for memory, is specifically activated by spatial learning in the hippocampus. This pathway shows selectivity for certain Wnt isoforms and brain regions, highlighting its role in long-term information storage.

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Last Updated: May 26, 2026

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
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06:09

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Published on: July 17, 2017

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Signaling

Background:

  • Transmembrane signaling pathways regulate neuronal plasticity and memory formation.
  • The Wnt signaling pathway plays a role in neuronal structure and function but its role in memory is understudied.

Purpose of the Study:

  • To investigate the role of Wnt signaling in spatial information storage.
  • To determine the specificity of Wnt signaling in learning and memory.

Main Methods:

  • Spatial learning task (water maze) in rodents.
  • Measurement of Wnt isoform levels in specific hippocampal subfields.
  • In vitro studies using primary hippocampal neurons to assess Wnt signaling in response to depolarization.

Main Results:

  • Spatial learning selectively increased Wnt 7 and Wnt 5a levels in the hippocampus, but not Wnt 3.
  • Wnt 7 elevation was specific to granule cells and occurred 7 and 30 days post-learning.
  • Neuronal depolarization in vitro increased Wnt levels and puncta, suggesting activity-dependent Wnt signaling and trafficking.

Conclusions:

  • Wnt signaling is specifically involved in spatial memory formation.
  • The Wnt pathway's role in memory is selective based on behavior, brain region, and Wnt isoform.
  • Activity-dependent Wnt signaling in neurons may contribute to long-term memory storage.