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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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Secondary binding sites for heavily modified triplex forming oligonucleotides

Antonia S Cardew1, Tom Brown, Keith R Fox

  • 1Centre for Biological Sciences, Life Sciences Building, University of Southampton, Southampton SO17 1BJ, UK.

Nucleic Acids Research
|December 20, 2011
PubMed
Summary

Synthetic oligonucleotides with specific amino modifications, like bis-amino-U, significantly enhance DNA triple helix stability and binding affinity. Researchers identified sequences with A(n) tracts bound by these modified oligonucleotides, confirming their effectiveness.

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