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Updated: May 26, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
Allergic contact dermatitis mimicking angioedema due to paraphenylendiamine hypersensitivity: a case report
Gulsen Tukenmez Demirci1, Ilknur Kivanc Altunay, Guldehan Atis
1Dermatology, Sisli Etfal Training and Research Hospital, Istanbul, Turkey. gulsentukenmez@yahoo.com
Abstract:
Active sensitization to paraphenylendiamine (PPD) and related compounds from temporary black henna tattoos has become an epidemic in the recent years. Hair dyes also include PPD like black henna tatoos which cause allergic contact dermatitis. Skin lesions of allergic contact dermatitis from PPD are mostly seen as an exudative erythema, an erythema multiforme-like eruption or a bullous contact dermatitis. We, herein, report a 27 year-old woman with an angioedema-like reaction occurring after the first exposure to hair dye who was unaware of being previously sensitized to PPD from black henna tattoo.
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