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Updated: May 26, 2026

Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes
Published on: September 12, 2018
Gold catalysis in total synthesis--an update.
Matthias Rudolph1, A Stephen K Hashmi
1Organisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
This review highlights the growing use of gold catalysis in organic synthesis. It examines how gold catalysts activate substrates in newly developed synthetic methods.
Area of Science:
- Organic Chemistry
- Catalysis
Background:
- Gold catalysis has emerged as a powerful tool in modern organic synthesis.
- The development of new gold-catalyzed reactions is rapidly expanding.
Purpose of the Study:
- To critically review the recent advancements in gold catalysis for total synthesis.
- To elucidate the mechanistic pathways of substrate activation by gold catalysts in novel methods.
Main Methods:
- Comprehensive literature search and critical analysis of existing studies.
- Focus on newly developed gold-catalyzed reactions and their applications in total synthesis.
Main Results:
- A significant increase in the application of gold catalysis for complex molecule synthesis.
- Detailed discussion on the diverse modes of substrate activation by gold species.
Conclusions:
- Gold catalysis offers versatile and efficient strategies for total synthesis.
- Understanding substrate activation mechanisms is key to designing new gold-catalyzed transformations.
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