Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Negative and Cognitive Symptoms of Schizophrenia

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...

Biological Causes of Schizophrenia

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.

Psychological and Sociocultural Causes of Schizophrenia

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Relationship among Sleep Disturbance, Stress, and Suicidal Ideation in Clinical High Risk for Psychosis.

Schizophrenia bulletin open·2026

Same author

Sex Differences in Psychopathology and Neurocognition in Community Youth With Autism Spectrum Disorder.

Autism research : official journal of the International Society for Autism Research·2026

Same author

Cannabis use and glutamate across the psychosis spectrum: in vivo evidence from 7T proton magnetic resonance spectroscopy.

Molecular psychiatry·2026

Same author

An open, fully-processed data resource for studying mood and sleep variability in the developing brain.

Aperture neuro·2026

Same author

Weight Change Between Pregnancies and Mortality Over 50 Years of Follow-Up.

Obesity (Silver Spring, Md.)·2026

Same author

Prevalence of inflammatory bowel disease across states: estimates based on claims database.

Inflammatory bowel diseases·2026

Search research articles

Related Experiment Video

Updated: May 26, 2026

Development of a Virtual Reality Assessment of Everyday Living Skills

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Computerized neurocognitive test performance in schizophrenia: a lifespan analysis.

Farzin Irani¹, Colleen M Brensinger, Jan Richard

¹Department of Psychiatry, Neuropsychiatry Section, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA. firani@upenn.edu

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry

|December 21, 2011

Summary

Computerized neurocognitive batteries reveal stable cognitive dysfunction in schizophrenia patients across all ages. Older patients show slower working memory but faster emotion processing, with fewer differences from healthy individuals after age 60.

More Related Videos

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills

Published on: February 13, 2020

Related Experiment Videos

Last Updated: May 26, 2026

Development of a Virtual Reality Assessment of Everyday Living Skills

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills

A Computerized Functional Skills Assessment and Training Program Targeting Technology Based Everyday Functional Skills

Published on: February 13, 2020

Area of Science:

Neuroscience
Psychiatry
Cognitive Science

Background:

Computerized neurocognitive batteries (CNBs) are increasingly used in large-scale studies.
Previous research established construct validity in younger schizophrenia patients, but not in older individuals.
CNBs offer new variables to clarify age-associated cognitive impairment.

Purpose of the Study:

To clarify age-associated cognitive impairment in schizophrenia across the lifespan using CNBs.
To assess the feasibility and utility of CNBs in large schizophrenia cohorts.
To investigate differences in cognitive performance between patients with schizophrenia and healthy comparisons across different age groups.

Main Methods:

A computerized neurocognitive battery (CNB) was administered to 624 patients with schizophrenia and 624 healthy comparison (HC) subjects aged 16-75.
The CNB assessed abstraction, mental flexibility, attention, working memory, recognition memory, language, visuospatial, and emotion processing.
Linear mixed effects models analyzed accuracy, response time, and efficiency scores, stratified by age.

Main Results:

Significant interactions were found for diagnosis, cognitive domain, and age group across all outcome variables.
Schizophrenia patients generally performed worse than HC subjects, except in the oldest age group (60+).
Older patients exhibited reduced working memory efficiency due to slower speed, not accuracy, and faster emotion processing compared to younger patients.

Conclusions:

Computerized assessments are feasible for large schizophrenia cohorts.
Schizophrenia is associated with stable, generalized neurocognitive dysfunction across the lifespan.
Age-related patterns include speed-accuracy trade-offs in working memory and enhanced emotional processing speed in older patients.