[The mesothelial cells]

Related Experiment Video

Updated: Oct 5, 2026

In vitro Mesothelial Clearance Assay that Models the Early Steps of Ovarian Cancer Metastasis
08:54

In vitro Mesothelial Clearance Assay that Models the Early Steps of Ovarian Cancer Metastasis

Published on: February 17, 2012

M C Jaurand1, J F Bernaudin, J Bignon

  • 1Unité INSERM 139, CHU Henri-Mondor, Maréchal-de-Lattre-de-Tassigny.

La Revue Du Praticien
|September 11, 1990
PubMed

Insights

This study examines mesothelial cells, their role in inflammation and cancer, particularly asbestos-related mesothelioma. It summarizes current research on mesothelial transformation and mesothelioma development, highlighting new molecular findings.

Area of Science:

  • Cell biology
  • Pathology
  • Molecular biology

Context:

  • Mesothelial cells line the pleura and play a role in inflammatory responses.
  • Asbestos exposure is a significant risk factor for mesothelioma.
  • The mechanisms of pleural fibrogenesis, such as pleural plaques, remain unclear.

Purpose:

  • To describe mesothelial cells in situ and discuss their functions.
  • To explore the relationship between mesothelial cells, inflammation, and carcinogenic transformation, especially concerning asbestos.
  • To summarize ongoing research into mesothelial transformation and mesothelioma genesis, focusing on recent molecular and cytogenetic discoveries.

Summary:

  • The abstract details the in situ description and functions of pleural mesothelial cells.
  • It links their inflammatory response to various agents, including asbestos, and their role in carcinogenic transformation.
  • Current research on mesothelial transformation and mesothelioma genesis, emphasizing molecular and cytogenetic findings, is reviewed.

Impact:

  • Provides a comprehensive overview of mesothelial cell functions and their involvement in disease.
  • Highlights the critical link between asbestos exposure and mesothelioma development.
  • Summarizes cutting-edge research, offering insights into the molecular mechanisms of mesothelioma.
  • Informs future research directions in understanding and potentially treating mesothelioma.

More Related Videos

Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity09:00

Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity

Published on: December 31, 2015

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Classification of Epithelial Tissues: Simple Epithelium01:30

Classification of Epithelial Tissues: Simple Epithelium

Simple epithelium consists of a single layer of cells that lines body cavities and blood vessels. The shape of the cells in the epithelium reflects the function of the tissue. Cells in simple squamous epithelium appear as thin scales with flat, elliptical nuclei that mirror the form of the cell.
Because of the thinness of the cells, simple squamous epithelium is present where the rapid passage of chemical compounds is observed. For example, the endothelium that lines the capillaries and vessels...
Embryonic Connective Tissues01:20

Embryonic Connective Tissues

During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development. Mesenchyme is...
Tissue Membranes01:27

Tissue Membranes

A tissue membrane is a thin layer of cells that covers the outside of the body, the organs, internal passageways that lead to the exterior of the body, and the lining of the moveable joint cavities. There are two basic types of tissue membranes— connective tissue and epithelial membranes.
Connective Tissue Membranes
The connective tissue membrane is formed solely from connective tissue. These membranes encapsulate organs, such as the kidneys, and line our movable joints. A synovial membrane is...
Pleura of the Lungs01:13

Pleura of the Lungs

The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...