Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Respiratory Volumes01:15

Respiratory Volumes

Respiratory volumes are crucial metrics, meticulously measured to quantify the air exchanged in and out of the lungs during various phases of the breathing cycle. These precise measurements are vital for assessing lung function, diagnosing respiratory conditions, and monitoring overall respiratory health. Each parameter provides specific insights into the mechanics of breathing and the functional capacity of the lungs.
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Factors Affecting Respiration01:24

Factors Affecting Respiration

Respiration is a crucial physiological function involving exchanging oxygen (O2) and carbon dioxide (CO2) between an organism and its environment. Various factors can impact this essential process:
Physical Assessment of the Respiratory Tract II: Inspection01:27

Physical Assessment of the Respiratory Tract II: Inspection

Physical assessment of the respiratory tract through inspection is a crucial step in understanding the patient's respiratory health. It provides insights into the functioning of the respiratory system, the musculoskeletal structure, and even the patient's nutritional status. This comprehensive approach involves observing several vital aspects: chest configuration, breathing patterns, respiratory rates, skin color, and use of accessory muscles.
Chest Configuration
The chest configuration can...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early life exposure to an episode of extreme air pollution and lung function later in childhood: the Hazelwood early life follow-up (ELF)study.

Environmental research·2026
Same author

Global Lung Function Initiative reference values for multiple breath washout indices.

The European respiratory journal·2024
Same author

Determinants of lung function development from birth to age 5 years: an interrupted time series analysis of a South African birth cohort.

The Lancet. Child & adolescent health·2024
Same author

Lung function changes in children exposed to mine fire smoke in infancy.

Respirology (Carlton, Vic.)·2024
Same author

Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.

Nature genetics·2023
Same author

Elevated leukotriene B4 and 8-isoprostane in exhaled breath condensate from preterm-born infants.

BMC pediatrics·2023
Same journal

Beyond the 5th percentile: rethinking diagnostic thresholds in pulmonary function testing.

The European respiratory journal·2026
Same journal

A Transcriptomic Atlas of Chronic Lung Allograft Dysfunction.

The European respiratory journal·2026
Same journal

Risk of cancer and mortality in patients with interstitial lung diseases: Danish cohort study.

The European respiratory journal·2026
Same journal

Proposing a minimal important difference in NTproBNP in pulmonary arterial hypertension.

The European respiratory journal·2026
Same journal

Unlocking growth potential: Ivacaftor therapy and developmental gains in lung and height in a cohort study of children and young adults with cystic fibrosis.

The European respiratory journal·2026
Same journal

Decoding the Lymphangioleiomyomatosis (LAM) Niche Microenvironment <i>via</i> Integrative Analysis of Single Cell Multiomics and Spatial Transcriptomics.

The European respiratory journal·2026
See all related articles

Related Experiment Video

Updated: May 26, 2026

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

Age- and height-based prediction bias in spirometry reference equations.

Philip H Quanjer1, Graham L Hall, Sanja Stanojevic

  • 1Dept of Pulmonary Diseases and Dept of Paediatrics, Erasmus Medical Centre, Erasmus University, Rotterdam, The Netherlands. pquanjer@xs4all.nl

The European Respiratory Journal
|December 21, 2011
PubMed
Summary
This summary is machine-generated.

Prediction bias in spirometry can be reduced by using a single equation across all ages and populations. Accurate measurement and recording of age and height are crucial for minimizing spirometry prediction bias.

More Related Videos

Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship
08:25

Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship

Published on: January 8, 2019

Conducting Respiratory Oscillometry in an Outpatient Setting
14:49

Conducting Respiratory Oscillometry in an Outpatient Setting

Published on: April 8, 2022

Related Experiment Videos

Last Updated: May 26, 2026

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship
08:25

Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship

Published on: January 8, 2019

Conducting Respiratory Oscillometry in an Outpatient Setting
14:49

Conducting Respiratory Oscillometry in an Outpatient Setting

Published on: April 8, 2022

Area of Science:

  • Pulmonary Function Testing
  • Biostatistics
  • Respiratory Medicine

Background:

  • Spirometry reference equations can exhibit prediction bias due to various factors.
  • Combining equations for different age groups, rounding values, and using self-reported height contribute to inaccuracies.

Purpose of the Study:

  • To assess the bias introduced by different spirometry prediction equation methodologies.
  • To quantify the impact of age grouping, age rounding, and height measurement errors on predicted spirometry values.

Main Methods:

  • Analysis of spirometric data from 55,136 healthy Caucasians against the Global Lungs Initiative (GLI) dataset.
  • Evaluation of 13 different prediction equations, assessing the effects of using whole-year versus decimal age and a 1% height bias.

Main Results:

  • Prediction bias in children ranged from -22% to +17%.
  • Switching equations at age 18 caused significant bias (-14% to +38%).
  • Age rounding and height overestimation introduced biases of -8% to +7% and +1% to +40%, respectively.

Conclusions:

  • A single, universal spirometry equation minimizes prediction bias across diverse populations and age groups.
  • Accurate measurement and recording of patient age and height are essential for reliable spirometry results.