Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Graves' Disease I: Introduction

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Graves Disease II: Pathophysiology

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

Hypothyroidism II: Pathophysiology

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...

Hyperthyroidism II: Pathophysiology

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...

Functions of Thyroid Hormones

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Multifocal Infantile Hemangioma - Presentation of 4 Cases and Review of the Selected Literature.

Acta dermatovenerologica Croatica : ADC·2024

Same author

Hand, Foot, and Mouth Disease in Children: Clinical Characteristics of an Outbreak in Novi Sad, Serbia.

Acta dermatovenerologica Croatica : ADC·2023

Same author

Infantile Hemangiomas with Minimal or Arrested Growth - Do They Occur More Often in Premature Infants Than It Seemed?

Acta dermatovenerologica Croatica : ADC·2023

Same author

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Macimorelin in Children with Suspected Growth Hormone Deficiency: An Open-Label, Group Comparison, Dose-Escalation Trial.

Hormone research in paediatrics·2021

Same author

Report of two siblings with APECED in Serbia: is there a founder effect of c.769C>T AIRE genotype?

Italian journal of pediatrics·2021

Same author

First report on the nationwide prevalence of paediatric type 1 diabetes in Serbia and temporal trends of diabetes ketoacidosis at diagnosis-a multicentre study.

Journal of pediatric endocrinology & metabolism : JPEM·2021

Search research articles

Related Experiment Video

Updated: May 26, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Vitiligo and thyroid dysfunction in children and adolescents.

Sonja Prćić¹, Verica Djuran, Dragan Katanić

¹Department of Dermatovenereology, Institute for Child and Youth Health Care of Voivodina, Novi Sad, Serbia. buki97@eunet.rs

Acta Dermatovenerologica Croatica : ADC

|December 22, 2011

Summary

Thyroid dysfunction affects a quarter of children and adolescents with vitiligo, with Hashimoto's thyroiditis being common. Early screening for thyroid autoantibodies in pediatric vitiligo patients is recommended.

More Related Videos

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse

Published on: October 6, 2023

Related Experiment Videos

Last Updated: May 26, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse

Published on: October 6, 2023

Area of Science:

Pediatric Endocrinology
Dermatology
Autoimmune Diseases

Background:

The association between vitiligo and thyroid disease is established in adults.
Limited data exists on thyroid dysfunction prevalence in pediatric vitiligo patients.

Purpose of the Study:

To determine the prevalence of thyroid dysfunction in children and adolescents diagnosed with vitiligo.
To identify potential predisposing factors for thyroid dysfunction in this pediatric cohort.

Main Methods:

Retrospective analysis of 75 pediatric patients with vitiligo.
Inclusion of physical examinations, thyroid ultrasonography, and thyroid function tests.
Statistical analysis to compare patient groups.

Main Results:

Thyroid parameter alterations were observed in 25.33% of the pediatric vitiligo patients.
Hashimoto's thyroiditis was diagnosed in 14.66% of patients, often associated with non-segmental vitiligo.
Upper limb vitiligo onset was significantly more frequent in patients with Hashimoto's thyroiditis.

Conclusions:

Thyroid dysfunction is prevalent in children and adolescents with vitiligo.
Screening for thyroid autoantibodies is advisable in pediatric patients with vitiligo, as vitiligo may precede thyroid disease.
Early detection can facilitate timely management of associated thyroid conditions.