Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Adult Stem Cells

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Normothermic versus hypothermic machine perfusion in kidney transplantation: A randomized controlled trial.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2025

Same author

Modeling kidney fibrosis and tubular regeneration in iPSC-derived kidney organoids.

Stem cell research & therapy·2025

Same author

Cellular Responses During Kidney Normothermic Machine Perfusion Reflect Graft Outcomes.

Kidney international reports·2025

Same author

Metabolite-enhanced normothermic machine perfusion improves kidney transplant viability.

JCI insight·2025

Same author

Mesenchymal stromal cell-derived membrane particles suppress kidney fibrosis.

Stem cell research & therapy·2025

Same author

(Pro)renin, Erythropoietin, Vitamin D and Urodilatin Release From Human Donor Kidneys During Normothermic Machine Perfusion: Predictors of Early Post-Transplant Outcome?

Clinical transplantation·2025

Search research articles

Related Experiment Video

Updated: May 26, 2026

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

Mesenchymal stem cells: application for solid-organ transplantation.

Marieke Roemeling-van Rhijn¹, Willem Weimar, Martin J Hoogduijn

¹Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. m.vanrhijn@erasmusmc.nl

Current Opinion in Organ Transplantation

|December 22, 2011

Summary

This summary is machine-generated.

Mesenchymal stem cells (MSCs) show promise for improving solid-organ transplantation (SOT) outcomes, with early clinical trials initiated. Further research is needed to fully understand MSC therapy mechanisms in SOT patients.

More Related Videos

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Published on: September 1, 2017

An Enzymatic Method to Rescue Mesenchymal Stem Cells from Clotted Bone Marrow Samples

An Enzymatic Method to Rescue Mesenchymal Stem Cells from Clotted Bone Marrow Samples

Published on: April 12, 2015

Related Experiment Videos

Last Updated: May 26, 2026

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Published on: September 1, 2017

An Enzymatic Method to Rescue Mesenchymal Stem Cells from Clotted Bone Marrow Samples

An Enzymatic Method to Rescue Mesenchymal Stem Cells from Clotted Bone Marrow Samples

Published on: April 12, 2015

Area of Science:

Immunology
Regenerative Medicine
Transplantation Science

Background:

Mesenchymal stem or stromal cells (MSCs) possess immunomodulatory and regenerative properties.
These characteristics position MSCs as a potential cell therapeutic agent for solid-organ transplantation (SOT).

Purpose of the Study:

To review recent preclinical and clinical studies evaluating the applicability of MSCs in SOT.
To summarize current understanding of MSC mechanisms and clinical trial progress in SOT.

Main Methods:

Review of preclinical animal transplant studies.
Analysis of in-vitro research on MSC mechanisms (paracrine, cell-dependent, migration, immunogenicity).
Summary of registered phase I/II clinical trials and published clinical data in SOT.

Main Results:

Animal studies suggest MSCs can enhance SOT outcomes.
In-vitro studies provide insights into MSC action, migration, and immunogenicity relevant to SOT.
Six clinical trials are registered for MSCs in SOT, with initial patient data now available.

Conclusions:

MSCs represent a promising cell therapy for SOT, with clinical trials underway.
The precise mechanisms of MSC therapy in SOT require further elucidation.
Continued basic and clinical research is essential for optimizing MSC therapy in SOT.