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Long-term outcome after pancreas transplantation
Angelika C Gruessner1, David E R Sutherland, Rainer W G Gruessner
1College of Public Health, University of Arizona, 1295 N. Martin Ave, Tucson, AZ 85724-5163, USA. acgruess@email.arizona.edu
Current Opinion in Organ Transplantation
|December 22, 2011
Summary
Pancreas transplantation can restore normal blood sugar levels in diabetic patients. Careful donor selection is key to improving both short-term and long-term pancreas graft function for better metabolic control.
Area of Science:
- Transplantation immunology
- Endocrinology
- Nephrology
Background:
- Pancreas transplantation is the only definitive treatment for insulin-dependent diabetes mellitus.
- Limited data exists on factors influencing long-term pancreas graft function beyond short-term survival.
Purpose of the Study:
- To identify factors distinguishing short-term from long-term pancreas graft function.
- To analyze trends in pancreas transplant graft survival.
Main Methods:
- Analysis of 18,159 pancreas transplants from the International Pancreas Transplant Registry (1978-2005).
- Evaluation of short-term and long-term graft function rates.
- Assessment of donor and recipient factors impacting graft survival.
Main Results:
- Significant improvements in long-term graft function observed over time.
- 5, 10, and 20-year graft function rates reported for different transplant types.
- Deceased donor quality, recipient age, ethnicity, and induction therapy impacted long-term outcomes.
Conclusions:
- Careful donor selection is crucial for achieving successful long-term pancreas graft function.
- Optimizing donor factors can lead to sustained normoglycemia in diabetic patients.
- Recipient characteristics and induction therapy also play a role in pancreas transplant success.
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