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Intraventricular hemorrhage in preterm infants: coagulation perspectives

Amir A Kuperman1, Gili Kenet, Emmanuel Papadakis

  • 1Pediatric Hematology Clinic, Thrombosis and Hemostasis Service, Institute of Hematology, Western Galilee Hospital, Naharriya, Israel.

Seminars in Thrombosis and Hemostasis
|December 22, 2011
PubMed

Insights

Immature coagulation systems in premature infants may increase intraventricular hemorrhage (IVH) risk. This review examines hemostatic agents for potential IVH prevention and treatment in preterm neonates.

Area of Science:

  • Neonatal Medicine
  • Hematology
  • Pediatric Neurology

Background:

  • Severe coagulation deficiency is linked to intraventricular hemorrhage (IVH) in premature newborns.
  • High-grade IVH correlates with coagulation derangements in extremely low birth weight infants.

Purpose of the Study:

  • To review the immature hemostatic system's role in IVH development in preterm infants.
  • To explore the potential of hemostasis-affecting agents for IVH therapy or prevention.

Main Methods:

  • Review of findings from small, open-label interventional studies.
  • Analysis of agents including ethamsylate, vitamin K, fresh frozen plasma, recombinant activated factor VII, and prothrombin complex concentrate.
  • Focus on the impact of these agents on the premature coagulation system.

Main Results:

  • The review synthesizes data on the effects of various hemostatic agents on preterm infant coagulation.
  • Evidence from interventional studies is examined regarding therapeutic potential.
  • The immature hemostatic system's specific contributions to IVH are discussed.

Conclusions:

  • The immature hemostatic system is relevant to IVH in preterm infants.
  • Hemostatic agents show potential for IVH prevention and treatment.
  • Further research into these agents is warranted for neonatal care.

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