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Calcium, phosphate, and vitamin D.

R S Goldsmith

    The Orthopedic Clinics of North America
    |April 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Recent advances illuminate vitamin D metabolism and its role in bone diseases like rickets and osteomalacia. Further research is needed to understand the direct effects of vitamin D metabolites on bone mineralization.

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    Area of Science:

    • Biochemistry
    • Endocrinology
    • Bone Metabolism

    Background:

    • Significant progress in understanding vitamin D metabolism and its interactions with calcium, phosphate, and parathyroid hormone over the past decade.
    • Therapeutic trials with vitamin D metabolites have provided insights into their role in rickets and osteomalacia.

    Purpose of the Study:

    • To review the current understanding of vitamin D metabolism and its clinical implications.
    • To explore the mechanisms by which vitamin D metabolites influence bone mineralization.
    • To discuss potential defects in vitamin D metabolism in renal insufficiency.

    Main Methods:

    • Review of recent literature on vitamin D metabolism and bone diseases.
    • Analysis of findings from therapeutic trials involving vitamin D metabolites.

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  • Discussion of biochemical pathways and clinical observations.

    • Main Results:

    • Knowledge of vitamin D metabolism and its interaction with key regulators has advanced significantly.
    • The involvement of vitamin D metabolites in rickets and osteomalacia is increasingly understood.
    • The precise mechanisms of how vitamin D metabolites affect bone mineralization are not fully elucidated, though direct effects are likely.

    Conclusions:

    • A deficiency in 1alpha-hydroxylase may not be the sole defect in renal insufficiency.
    • Further investigation is required to identify potential uncharacterized metabolites or metabolic defects in kidney disease.
    • While indirect effects on serum calcium and phosphate are known, direct influence of vitamin D metabolites on bone mineralization is probable.