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High-affinity fluorescent ligands for the 5-HT(3) receptor

Jonathan Simonin1, Sanjeev Kumar V Vernekar, Andrew J Thompson

  • 1Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.

Bioorganic & Medicinal Chemistry Letters
|December 23, 2011
PubMed
Summary

Researchers synthesized novel fluorescent ligands targeting the serotonin 5-HT(3) receptor. These compounds, including granisetron conjugates, exhibit high quantum yields and strong binding affinity for the human 5-HT(3)AR.

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