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Updated: May 26, 2026

Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg
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Venous leg ulcers.

E Andrea Nelson1

  • 1University of Leeds, Leeds, UK.

BMJ Clinical Evidence
|December 23, 2011
PubMed
Summary
This summary is machine-generated.

This systematic review evaluates various treatments for venous leg ulcers, including compression, skin replacements, and oral medications. It provides evidence on the effectiveness and safety of interventions to manage and prevent these chronic wounds.

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Area of Science:

  • Vascular Medicine
  • Dermatology
  • Evidence-Based Medicine

Background:

  • Leg ulcers are commonly linked to venous issues but arterial disease affects 20% of patients.
  • Prevalence of active leg ulcers is 1.5–3.0/1000 people, increasing with age.
  • Understanding diverse etiologies is crucial for effective leg ulcer management.

Purpose of the Study:

  • To systematically review the effectiveness of standard, adjuvant, and organizational interventions for venous leg ulcers.
  • To assess the impact of self-help advice on patients receiving usual care.
  • To evaluate interventions aimed at preventing the recurrence of venous leg ulcers.

Main Methods:

  • Conducted a systematic review of 101 studies including systematic reviews, RCTs, and observational studies.
  • Searched major databases (Medline, Embase, Cochrane Library) up to June 2011.
  • Included harms alerts from regulatory agencies (FDA, MHRA) and performed GRADE evaluation.

Main Results:

  • Evaluated a wide range of interventions including compression therapies, skin replacements, debridement, dressings, and various oral and topical treatments.
  • Assessed the effects of interventions like intermittent pneumatic compression, larval therapy, and leg ulcer clinics.
  • Included self-help advice on leg elevation, activity, diet, smoking cessation, and weight reduction.

Conclusions:

  • Presents comprehensive information on the effectiveness and safety of numerous interventions for venous leg ulcers.
  • Highlights the breadth of available treatments, from physical methods like compression to advanced therapies like skin grafting and negative pressure wound therapy.
  • Emphasizes the importance of a systematic approach to evidence evaluation for managing complex leg ulcer cases.