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[Diseases caused by Streptococcus pyogenes in Norway, 1975-1989. A microbiologic and epidemiologic survey]
Abstract:
The article briefly surveys the epidemiology of Streptococcus pyogenes caused disease in Norway during the last 15 years based on notification data, with emphasis on the nation-wide outbreak in 1987-88 caused by mucoid M-1 organisms. During the season S. pyogenes infections was 60% higher than expected. The number of bacteraemia cases, many with fulminant septicaemia, showed an almost threefold increase compared with earlier years. Unusual clinical manifestations such as necrotising fasciitis, pneumonia with empyema, primary peritonitis and meningitis also occurred. We briefly review the known virulence factors of S. pyogenes in an attempt to improve our understanding of the shift in clinical manifestations and occurrence of the disease.
Insights
Streptococcus pyogenes infections surged in Norway, with a notable 1987-88 outbreak. This led to increased severe cases and unusual clinical conditions, prompting a review of bacterial virulence factors.
Area of Science:
- Infectious Diseases
- Microbiology
- Epidemiology
Context:
- Focuses on Streptococcus pyogenes (group A Streptococcus) epidemiology in Norway over 15 years.
- Highlights a significant nationwide outbreak in 1987-88 linked to mucoid M-1 strains.
Purpose:
- To survey the epidemiology of Streptococcus pyogenes infections in Norway.
- To understand the shift in clinical manifestations and disease occurrence by reviewing virulence factors.
Summary:
- Observed a 60% increase in S. pyogenes infections and a threefold rise in bacteremia cases, including severe sepsis.
- Documented unusual clinical presentations like necrotizing fasciitis, pneumonia with empyema, peritonitis, and meningitis.
Impact:
- Provides insights into the changing epidemiology and clinical spectrum of group A Streptococcus infections.
- Aids in understanding the role of bacterial virulence in disease patterns.