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Biogenesis of MiRNA-195 and its role in biogenesis, the cell cycle, and apoptosis

Jun-Feng He1, Yu-Mei Luo, Xin-Hong Wan

  • 1Department of Cardiology, Shenzhen Longgang District People's Hospital, Guang Dong Medicine College, Shenzhen, 518172, People's Republic of China.

Journal of Biochemical and Molecular Toxicology
|December 23, 2011
PubMed

Insights

microRNA-195 (miR-195) plays a key role in diseases like cancer by regulating cell cycle and apoptosis. This review details miR-195

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • microRNA-195 (miR-195) is part of the miR-15/16/195/424/497 family.
  • miR-195 is implicated in various diseases, including cancers, heart failure, and schizophrenia.
  • It regulates critical cellular processes such as cell cycle, apoptosis, and proliferation.

Purpose of the Study:

  • To review the current research on miR-195's function.
  • To elucidate the mechanisms of miR-195 in cell cycle regulation and apoptosis.

Main Methods:

  • Literature review of recent studies on miR-195.
  • Analysis of miR-195's confirmed target genes (WEE1, CDK6, Bcl-2).

Main Results:

  • miR-195 targets proteins involved in cell cycle control and apoptosis.
  • Confirmed targets WEE1, CDK6, and Bcl-2 mediate miR-195's effects.
  • The precise mechanisms of miR-195 action require further investigation.

Conclusions:

  • miR-195 is a significant regulator of cell cycle and apoptosis.
  • Understanding miR-195 mechanisms is crucial for disease insights.
  • Further research is needed to fully comprehend miR-195's role in pathology.

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